Neonatal infections: group B streptococcus.

نویسندگان

  • Paul Trafford Heath
  • Luke Anthony Jardine
چکیده

INTRODUCTION One in four women carry group B streptococci vaginally, which can infect the amniotic fluid even if the membranes are intact, or can infect the baby during delivery, causing sepsis, pneumonia, or meningitis. Very-low-birthweight infants are at much higher risk of infection or mortality, with up to 3% infected, and mortality rates of up to 30% even with immediate antibiotic treatment. Late-onset group B streptococcal infection begins after 7 to 9 days, and usually causes fever or meningitis, but is less often fatal compared with early infection. METHODS AND OUTCOMES We conducted a systematic review and aimed to answer the following clinical question: What are the effects of prophylactic treatment of asymptomatic neonates less than 7 days old with known risk factors for group B streptococcal infection? We searched: Medline, Embase, The Cochrane Library and other important databases up to April 2010 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). RESULTS We found 12 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions. CONCLUSIONS In this systematic review we present information relating to the effectiveness and safety of the following interventions: different antibiotics, monitoring and selective treatment, and routine antibiotic prophylaxis.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Group B streptococcal neonatal infections in Rio Grande do Sul, Brazil.

UNLABELLED Group B Streptococcus is the most common pathogen found in neonatal sepsis in North America. OBJECTIVES We describe 15 cases of neonatal infections by Group B Streptococcus (Streptococcus agalactiae) at a Neonatal Intensive Care Unit of a public and teaching hospital. METHODS We conducted a study at Hospital de Clínicas de Porto Alegre, from January 1st, 1996 to June 30, 1999. Di...

متن کامل

Maternal Carriage and Neonatal Colonization of Streptococcus agalactiae in Tabriz, Northwest Iran

Group B Streptococcus (GBS) is a major cause of severe systemic and local infections in newborns. This study was performed to evaluate the presence of GBS in pregnant women and their newborns in Tabriz, Iran. Vaginal specimens were collected from 965 women who were candidate for vaginal delivery for bacteriological study of group B streptococci. Several samples from various sites of the newborn...

متن کامل

Investigating the Rate of Group B Streptococcus in Below 3 Months Year Old Infants with Sepsis Clinical Symptoms Hospitalized in Ghaem Hospital of Mashhad

Introduction Group B streptococcus is the main reason of neonatal infection in developed countries and causes a widespread clinical indications. In developing countries such as Iran, its rate of appearance is not determined. With regard to colonization and the relative high epithelia of group B streptococcus, it is likely that the incidence of group B streptococcus in neonatal sepsis is so high...

متن کامل

Epidemiologic Pattern of Vaginal Colonization by Group B Streptococcus in Pregnant Women in Hamadan, Central West of Iran

Group B Streptococcus (GBS) is a leading cause of serious neonatal infections. Although great progress has been made in preventing prenatal GBS, its colonization rate in different regions ofIran remains unknown. The objective of this study was to determine the colonization rate of GBS in pregnant women in Hamadan city, Central west of Iran. A group of 544 pregnant women were randomly selected a...

متن کامل

A survey on the prevalence of group B Streptococcus in pregnant women referred to the obstetrics and Gynecology ward at babol Ayatollah Rouhani hospital

OBJECTIVES:Prenatal infections are one of the fundamental causes of early puerperal complications in mothers and neonates. These infections are mostly due to colonized organisms in pregnant woman's genitor-urinary system. The aim of this study was to determine the incidence of streptococcus group B (GBS) colonization in parturient women and the rate of pathogen transmission to the newborn. METH...

متن کامل

Protection from group B streptococcal infection in neonatal mice by maternal immunization with recombinant Sip protein.

The protective potential of antibodies directed against group B streptococcus (GBS) Sip surface protein was determined by using the mouse neonatal infection model. Rabbit Sip-specific antibodies administered passively to pregnant mice protected their pups against a GBS lethal challenge. In addition, active immunization with purified recombinant Sip protein of female CD-1 mice induced the produc...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • BMJ clinical evidence

دوره 2010  شماره 

صفحات  -

تاریخ انتشار 2010